Gene of the month: <i>TLE 1</i>

TLE 1 is the human homologue belonging to a family of four genes and located on chromosome 9q21. It consists 19 exons. Although it does not bind directly DNA, acts as repressor several signalling pathways via transcription factors. TLE1 protein has physiological roles in embryogenesis, haematopoiesis, general differentiation, both neuronal eye development. Much attention was focused its expression tumour cell nuclei synovial sarcoma (SS). However, other soft tissue tumours that do share morphological similarity with SS also display nuclear immunoreactivity for TLE1; hence, caution interpretation advocated.